Effect and Mechanism of Safranal on ISO-Induced Myocardial Injury

Overview

Working with Professor Ketao Ma at Shihezi University, I studied whether safranal could protect against isoproterenol (ISO)-induced myocardial injury and which mechanisms might be involved.

Approach

Network pharmacology and molecular docking were used to investigate candidate targets and pathways. The study also tested safranal in experimental models of myocardial injury.

I analyzed candidate targets and pathways and contributed to cell-culture experiments. The published study used H9c2 cells to investigate myocardial injury.

Published study

The paper reports reduced myocardial injury and apoptosis in experimental models, with evidence linking safranal's effects to downregulation of TNF signaling.

I co-authored the paper, published in the Journal of Ethnopharmacology, 2023.